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Target
Programmed cell death 1 ligand 1
Ligand
BDBM365881
Substrate
n/a
Meas. Tech.
Homogenous Time-Resolved Fluorescence (HTRF) Binding Assay
IC50
555±n/a nM
Citation
 Chupak, LS; Zheng, X Compounds useful as immunomodulators US Patent  US9872852 Publication Date 1/23/2018 
Target
Name:
Programmed cell death 1 ligand 1
Synonyms:
B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1
Type:
PROTEIN
Mol. Mass.:
33278.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109807
Residue:
290
Sequence:
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
  
Inhibitor
Name:
BDBM365881
Synonyms:
2-[4-({[(4- hydroxyphenyl)methyl]amino} methyl)-3,5- dimethoxyphenoxymethyl]-6- phenylbenzonitrile | US9872852, Example 133
Type:
Small organic molecule
Emp. Form.:
C30H28N2O4
Mol. Mass.:
480.5543
SMILES:
COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNCc1ccc(O)cc1
Structure:
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