Target
Bcl-2-like protein 1
Ligand
BDBM21418
Substrate
Fluorescein-labeled BAD peptide
Meas. Tech.
Fluorescence Polarization (FP) Assay and FL5.12 Cellular Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
<0.5±n/a nM
IC50
71±n/a nM
EC50
150±50 nM
Citation
 Bruncko, MOost, TKBelli, BADing, HJoseph, MKKunzer, AMartineau, DMcClellan, WJMitten, MNg, SCNimmer, PMOltersdorf, TPark, CMPetros, AMShoemaker, ARSong, XWang, XWendt, MDZhang, HFesik, SWRosenberg, SHElmore, SW Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. J Med Chem 50:641-62 (2007) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM21418
Synonyms:
4-Alkyl-4-methoxypiperidine derivative, 8j | N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene)sulfonyl]-4-{4-methoxy-4-[(2-methylphenyl)methyl]piperidin-1-yl}benzamide
Type:
Small organic molecule
Emp. Form.:
C39H47N5O6S2
Mol. Mass.:
745.95
SMILES:
COC1(Cc2ccccc2C)CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN(C)C)CSc2ccccc2)c(c1)[N+]([O-])=O |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Fluorescein-labeled BAD peptide
Synonyms:
n/a
Type:
fluorescein-labeled probe
Mol. Mass.:
3078.53
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
NLWAAQRYGRELRRMSDKFITCFVD