Target
Bcl-2-like protein 1
Ligand
BDBM21429
Substrate
Fluorescein-labeled BAD peptide
Meas. Tech.
Fluorescence Polarization (FP) Assay and FL5.12 Cellular Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
<0.5±n/a nM
IC50
520±n/a nM
EC50
1100±50 nM
Citation
 Bruncko, MOost, TKBelli, BADing, HJoseph, MKKunzer, AMartineau, DMcClellan, WJMitten, MNg, SCNimmer, PMOltersdorf, TPark, CMPetros, AMShoemaker, ARSong, XWang, XWendt, MDZhang, HFesik, SWRosenberg, SHElmore, SW Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. J Med Chem 50:641-62 (2007) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM21429
Synonyms:
4-Piperidinebenzylidene derivative, 10h | 4-{4-[(2-cyanophenyl)methylidene]piperidin-1-yl}-N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene)sulfonyl]benzamide
Type:
Small organic molecule
Emp. Form.:
C38H40N6O5S2
Mol. Mass.:
724.891
SMILES:
[#6]-[#7](-[#6])-[#6]-[#6]-[#6@H](-[#6]-[#16]-c1ccccc1)-[#7]-c1ccc(cc1-[#7+](-[#8-])=O)S(=O)(=O)[#7]-[#6](=O)-c1ccc(cc1)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]/c1ccccc1C#N |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Fluorescein-labeled BAD peptide
Synonyms:
n/a
Type:
fluorescein-labeled probe
Mol. Mass.:
3078.53
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
NLWAAQRYGRELRRMSDKFITCFVD