Reaction Details Report a problem with these data
Target
Galectin-3
Ligand
BDBM21524
Substrate
BDBM21520
Meas. Tech.
Fluorescence Polarization Assay
pH
7.2±n/a
Temperature
297.15±n/a K
Kd
43000±n/a nM
Citation
 Salameh, BA; Sundin, A; Leffler, H; Nilsson, UJ Thioureido N-acetyllactosamine derivatives as potent galectin-7 and 9N inhibitors. Bioorg Med Chem 14:1215-20 (2006) [PubMed]  Article 
Target
Name:
Galectin-3
Synonyms:
LEG3_HUMAN | LGALS3 | MAC2
Type:
Enzyme
Mol. Mass.:
26156.54
Organism:
Homo sapiens (Human)
Description:
P17931
Residue:
250
Sequence:
MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDIDLTSASYTMI
  
Inhibitor
Name:
BDBM21524
Synonyms:
N-[(2R,3R,4R,5S,6R)-5-{[(2S,3R,4S,5R,6R)-4-[(diethylcarbamothioyl)amino]-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4-hydroxy-6-(hydroxymethyl)-2-methoxyoxan-3-yl]acetamide | Thioureido N-acetyllactosamine derivative, 8
Type:
n/a
Emp. Form.:
C20H37N3O10S
Mol. Mass.:
511.587
SMILES:
CCN(CC)C(=S)N[C@H]1[C@@H](O)[C@@H](CO)O[C@@H](O[C@H]2[C@H](O)[C@@H](NC(C)=O)[C@H](OC)O[C@@H]2CO)[C@@H]1O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM21520
Synonyms:
fluorescein-tagged saccharide
Type:
fluorescent probe
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: