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Targetpoly(ADP-ribose) glycohydrolase (PARG)
LigandBDBM371485
Substrate/Competitorn/a
Meas. Tech.PARG Assay
IC50 25.0±n/a nM
Citation McGonagle, AEJordan, AWaszkowycz, BHutton, CWaddell, IHitchin, JRSmith, KMHamilton, NM 2,4-dioxo-quinazoline-6-sulfonamide derivatives as inhibitors of PARG US Patent US10239843 Publication Date 3/26/2019
More Info.:Get all data from this article,  Assay Method
 
poly(ADP-ribose) glycohydrolase (PARG)
Name:poly(ADP-ribose) glycohydrolase (PARG)
Synonyms:Poly(ADP-ribose) glycohydrolase
Type:Protein
Mol. Mass.:111107.13
Organism:Homo sapiens (Human)
Description:Q86W56
Residue:976
Sequence:
MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPG
RAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQ
HNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPE
QFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKS
CDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEP
ESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTK
GGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKA
EDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANH
TVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQ
TALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKI
ALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDIN
FNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHV
TYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNEC
LIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEK
MRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYF
TFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAV
ESCAETADHSGQRTGT
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  Blast E-value cutoff:
BDBM371485
NameBDBM371485
Synonyms:N-[1-(Fluoromethyl)cyclopropyl]-3-[(1-methylpyrazol-4-yl)methyl]-1-[(2-methylthiazol-5-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide | US10239843, Example 594
TypeSmall organic molecule
Emp. Form.C22H23FN6O4S2
Mol. Mass.518.584
SMILESCc1ncc(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(CF)CC2)s1
Structure
n/a