Target
ADP-ribosylhydrolase ARH3
Ligand
BDBM371469
Substrate
n/a
Meas. Tech.
ARH3 Assay
IC50
>150000±n/a nM
Citation
 McGonagle, AEJordan, AWaszkowycz, BHutton, CWaddell, IHitchin, JRSmith, KMHamilton, NM 2,4-dioxo-quinazoline-6-sulfonamide derivatives as inhibitors of PARG US Patent  US10239843 Publication Date 3/26/2019 
Target
Name:
ADP-ribosylhydrolase ARH3
Synonyms:
ADP-ribose glycohydrolase ARH3 | ADP-ribosylhydrolase 3 | ADPRHL2 | ADPRS | ADPRS_HUMAN | ARH3 | O-acetyl-ADP-ribose deacetylase ARH3 | Poly(ADP-ribose) glycohydrolase ARH3 | [Protein ADP-ribosylarginine] hydrolase-like protein 2 | [Protein ADP-ribosylserine] hydrolase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38934.22
Organism:
Homo sapiens (Human)
Description:
Q9NX46
Residue:
363
Sequence:
MAAAAMAAAAGGGAGAARSLSRFRGCLAGALLGDCVGSFYEAHDTVDLTSVLRHVQSLEPDPGTPGSERTEALYYTDDTAMARALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAGVVTVFKKLLNPKCRDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARLSAQLTHASSLGYNGAILQALAVHLALQGESSSEHFLKQLLGHMEDLEGDAQSVLDARELGMEERPYSSRLKKIGELLDQASVTREEVVSELGNGIAAFESVPTAIYCFLRCMEPDPEIPSAFNSLQRTLIYSISLGGDTDTIATMAGAIAGAYYGMDQVPESWQQSCEGYEETDILAQSLHRVFQKS
  
Inhibitor
Name:
BDBM371469
Synonyms:
N-[1-(Fluoromethyl)cyclopropyl]-1-(isothiazol-5-ylmethyl)-3-[(1-methylpyrazol-4-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide | US10239843, Example 578
Type:
Small organic molecule
Emp. Form.:
C21H21FN6O4S2
Mol. Mass.:
504.558
SMILES:
Cn1cc(Cn2c(=O)n(Cc3ccns3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1
Structure:
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