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TargetIndoleamine 2,3-dioxygenase 1
LigandBDBM21981
Substrate/CompetitorBDBM21974
Meas. Tech.Enzyme Inhibition Assay
pH6.5±n/a
Temperature310.15±n/a K
Ki 260±30 nM
Citation Carr, GChung, MKMauk, AGAndersen, RJ Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine a. J Med Chem51:2634-7 (2008) [PubMed]  Article
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Indoleamine 2,3-dioxygenase 1
Name:Indoleamine 2,3-dioxygenase
Synonyms:IDO | IDO-1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine-pyrrole 2,3-dioxygenase
Type:Enzyme
Mol. Mass.:45330.80
Organism:Homo sapiens (Human)
Description:n/a
Residue:403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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BDBM21981
NameBDBM21981
Synonyms:Tryptamine quinone, 21 | methyl 4-[3-(2-{[(benzyloxy)carbonyl]amino}ethyl)-4,7-dioxo-4,7-dihydro-1H-indol-5-yl]-3-methyl-2,5-dioxo-1-propylimidazolidine-4-carboxylate
TypeSmall organic molecule
Emp. Form.C27H28N4O8
Mol. Mass.536.5332
SMILESCCCN1C(=O)N(C)C(C(=O)OC)(C1=O)C1=CC(=O)c2[nH]cc(CCNC(=O)OCc3ccccc3)c2C1=O |t:16|
Structure
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BDBM21974
NameBDBM21974
Synonyms:(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid | CHEMBL54976 | L-tryptophan | US9138393, L-Tryptophan | US9144538, L-Tryptophan
TypeAmino Acid
Emp. Form.C11H12N2O2
Mol. Mass.204.2252
SMILESN[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Structure
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