Target
Monocarboxylate transporter 1
Ligand
BDBM22000
Substrate
BDBM21986
Meas. Tech.
Radioligand Filter Binding Assay
pH
7.8±n/a
Temperature
295.15±n/a K
Ki
0.10±n/a nM
Citation
 Guile, SDBantick, JRCheshire, DRCooper, MEDavis, AMDonald, DKEvans, REyssade, CFerguson, DDHill, SHutchinson, RIngall, AHKingston, LPMartin, IMartin, BPMohammed, RTMurray, CPerry, MWReynolds, RHThorne, PVWilkinson, DJWithnall, J Potent blockers of the monocarboxylate transporter MCT1: novel immunomodulatory compounds. Bioorg Med Chem Lett 16:2260-5 (2006) [PubMed]  Article 
Target
Name:
Monocarboxylate transporter 1
Synonyms:
MCT 1 | MCT1 | MOT1_HUMAN | Monocarboxylate transporter 1 | SLC16A1 | Solute carrier family 16 member 1
Type:
PROTEIN
Mol. Mass.:
53956.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1451367
Residue:
500
Sequence:
MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSWISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQEKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAFLLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKAAESPDQKDTDGGPKEEESPV
  
Inhibitor
Name:
BDBM22000
Synonyms:
7-[(3-hydroxypropyl)sulfanyl]-2-methyl-4-(2-methylpropyl)-6-(naphthalen-1-ylmethyl)-1H,2H,6H-pyrrolo[3,4-d]pyridazin-1-one | 7-[(3-hydroxypropyl)sulfanyl]-2-methyl-4-(2-methylpropyl)-6-(naphthalen-1-ylmethyl)-2,6-dihydro-1H-pyrrolo[3,4-d]pyridazin-1-one | Pyrrolo[3,4-d]pyridazin-1-one, 2
Type:
n/a
Emp. Form.:
C25H29N3O2S
Mol. Mass.:
435.582
SMILES:
CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3cccc4ccccc34)cc12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM21986
Synonyms:
5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methylpropyl)-6-(naphthalen-1-ylmethyl)-1H,2H,3H,4H,6H-pyrrolo[3,4-d]pyrimidine-2,4-dione | 5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methylpropyl)-6-(naphthalen-1-ylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione | CHEMBL85752 | Pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione, 1 | [3H]-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione
Type:
n/a
Emp. Form.:
C25H29N3O3S
Mol. Mass.:
451.581
SMILES:
CC(C)Cn1c2cn(Cc3cccc4ccccc34)c(SCCCO)c2c(=O)n(C)c1=O
Structure:
Search PDB for entries with ligand similarity: