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Target
Sphingosine 1-phosphate receptor 5
Ligand
BDBM22204
Substrate
BDBM22202
Meas. Tech.
S1P Receptor Binding Assay
Temperature
298.15±n/a K
IC50
5.2±n/a nM
Comments
extracted
Citation
 Li, Z; Chen, W; Hale, JJ; Lynch, CL; Mills, SG; Hajdu, R; Keohane, CA; Rosenbach, MJ; Milligan, JA; Shei, GJ; Chrebet, G; Parent, SA; Bergstrom, J; Card, D; Forrest, M; Quackenbush, EJ; Wickham, LA; Vargas, H; Evans, RM; Rosen, H; Mandala, S Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3. J Med Chem 48:6169-73 (2005) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 5
Synonyms:
EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41796.42
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
398
Sequence:
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
  
Inhibitor
Name:
BDBM22204
Synonyms:
1,2,4-oxadiazole based compound, 21 | 1-({4-[5-(4-tert-butylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acid
Type:
Small organic molecule
Emp. Form.:
C23H25N3O3
Mol. Mass.:
391.4629
SMILES:
CC(C)(C)c1ccc(cc1)-c1nc(no1)-c1ccc(CN2CC(C2)C(O)=O)cc1
Structure:
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Substrate
Name:
BDBM22202
Synonyms:
S1P | [32P]S1P | [33P]S1P | sphingosine-1-phosphate | sphingosine-1-phosphate, 32P labeled | sphingosine-1-phosphate, 33P labeled | {[(4Z)-2-amino-3-hydroxyoctadec-4-en-1-yl]oxy}phosphonic acid
Type:
radiolabeled ligand
Emp. Form.:
C18H38NO5P
Mol. Mass.:
379.4718
SMILES:
CCCCCCCCCCCCC\C=C/C(O)C(N)COP(O)(O)=O
Structure:
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