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Reaction Details
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TargetTransporter
LigandBDBM22396
Substrate/CompetitorBDBM22417
Meas. Tech.Ligand Binding Assay
Ki 920±n/a nM
Citation Gong, PKBlough, BEBrieaddy, LEHuang, XKuhar, MJNavarro, HACarroll, FI Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-[5-(substituted phenyl)thiazol-2-yl]tropanes. J Med Chem50:3686-95 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Transporter
Name:Transporter
Synonyms:NET | Norepinephrine transporter(NET)
Type:Multi-pass membrane protein
Mol. Mass.:69236.90
Organism:Rattus norvegicus (rat)
Description:Q63380
Residue:617
Sequence:
MLLARMKPQVQPELGGADQLPEQPLRPCKTADLLVVKERNGVQCLLASQDGDAQPRETWG
KEIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAW
NSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFA
IFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHL
VAQRDVRQFQLRHWLAI
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BDBM22396
NameBDBM22396
Synonyms:(1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophenyl)-1,3-thiazol-2-yl]-8-methyl-8-azabicyclo[3.2.1]octane | WIN 35,065-2 | WIN35,065-2 | Win 35,065 | methyl (1R,2S,3S,5S)-8-methyl-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate | troparil, 1R-(exo,exo)-isomer
TypeSmall organic molecule
Emp. Form.C16H21NO2
Mol. Mass.259.3434
SMILESCOC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1c1ccccc1)N2C |TLB:18:17:6.7:10.9.4|
Structure
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BDBM22417
NameBDBM22417
Synonyms:3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine | CHEMBL295467 | LY 135252 | LY 94939 | LY135252 | LY139602 | Nisoxetine | Nisoxetine Inhibitor | [3-(2-methoxyphenoxy)-3-phenylpropyl](methyl)amine | [3H]NISOXETINE | [3H]Nisoxetine | nisoxetine
Typeradiolabeled ligand
Emp. Form.C17H21NO2
Mol. Mass.271.3541
SMILESCNCCC(Oc1ccccc1OC)c1ccccc1
Structure
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