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TargetSphingosine 1-Phosphate Receptor 4
LigandBDBM22202
Substrate/CompetitorBDBM22202
Meas. Tech.[32P] S1P Binding Assay
pH7.5±n/a
Temperature277.15±n/a K
Ki 2.7±0.28 nM
Citation Kiuchi, MAdachi, KTomatsu, AChino, MTakeda, STanaka, YMaeda, YSato, NMitsutomi, NSugahara, KChiba, K Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate. Bioorg Med Chem13:425-32 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Sphingosine 1-Phosphate Receptor 4
Name:Sphingosine 1-phosphate receptor
Synonyms:EDG6 | Endothelial differentiation G-protein coupled receptor 6 | S1P receptor 4 | S1P receptor Edg-6 | S1P4 | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-6 | Sphingosine-1-phosphate receptor 4 | sphingosine-1-phosphate 4 S1P4
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41647.39
Organism:Homo sapiens (Human)
Description:n/a
Residue:384
Sequence:
MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLV
VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFL
REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLP
LLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRP
AARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNS
AVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDS
FRGSRSLSFRMREPLSSISSVRSI
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BDBM22202
NameBDBM22202
Synonyms:S1P | [32P]S1P | [33P]S1P | sphingosine-1-phosphate | sphingosine-1-phosphate, 32P labeled | sphingosine-1-phosphate, 33P labeled | {[(4Z)-2-amino-3-hydroxyoctadec-4-en-1-yl]oxy}phosphonic acid
Typeradiolabeled ligand
Emp. Form.C18H38NO5P
Mol. Mass.379.4718
SMILESCCCCCCCCCCCCC\C=C/C(O)C(N)COP(O)(O)=O
Structure
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BDBM22202
NameBDBM22202
Synonyms:S1P | [32P]S1P | [33P]S1P | sphingosine-1-phosphate | sphingosine-1-phosphate, 32P labeled | sphingosine-1-phosphate, 33P labeled | {[(4Z)-2-amino-3-hydroxyoctadec-4-en-1-yl]oxy}phosphonic acid
Typeradiolabeled ligand
Emp. Form.C18H38NO5P
Mol. Mass.379.4718
SMILESCCCCCCCCCCCCC\C=C/C(O)C(N)COP(O)(O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: