Target
L-lactate dehydrogenase
Ligand
BDBM23223
Substrate
BDBM23230
Meas. Tech.
Lactate Dehydrogenase Inhibition Assay
IC50
2030±n/a nM
Citation
 Choi, SRPradhan, AHammond, NLChittiboyina, AGTekwani, BLAvery, MA Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. J Med Chem 50:3841-50 (2007) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase
Synonyms:
Malate Dehydrogenase (pfMDH) | Malic dehydrogenase | pfMDH
Type:
Oxidoreductase
Mol. Mass.:
34043.75
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
313
Sequence:
MTKIALIGSGQIGAIVGELCLLENLGDLILYDVVPGIPQGKALDLKHFSTILGVNRNILGTNQIEDIKDADIIVITAGVQRKEGMTREDLIGVNGKIMKSVAESVKLHCSKAFVICVSNPLDIMVNVFHKFSNLPHEKICGMAGILDTSRYCSLIADKLKVSAEDVNAVILGGHGDLMVPLQRYTSVNGVPLSEFVKKNMISQNEIQEIIQKTRNMGAEIIKLAKASAAFAPAAAITKMIKSYLYNENNLFTCAVYLNGHYNCSNLFVGSTAKINNKGAHPVEFPLTKEEQDLYTESIASVQSNTQKAFDLIK
  
Inhibitor
Name:
BDBM23223
Synonyms:
7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-yl)naphthalen-2-yl]-2,3,8-trihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carbaldehyde | CHEMBL51483 | Gossypol | Gossypol (C9) | Gossypol, 4 | Pogosin | Tash 1 | US9115061, Gossypol | cid_3503
Type:
Small organic molecule
Emp. Form.:
C30H30O8
Mol. Mass.:
518.5544
SMILES:
CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)-c1c(C)cc2c(C(C)C)c(O)c(O)c(C=O)c2c1O |(-4.44,-1.63,;-5.78,-.86,;-7.11,-1.63,;-5.78,.68,;-7.11,1.45,;-8.44,.68,;-7.11,2.99,;-8.44,3.76,;-5.78,3.76,;-5.78,5.3,;-4.44,6.07,;-4.44,2.99,;-3.11,3.76,;-3.11,5.3,;-1.77,2.99,;-1.77,1.45,;-.44,.68,;-3.11,.68,;-4.44,1.45,;-.44,3.76,;-.44,5.3,;-1.77,6.07,;.89,6.07,;2.23,5.3,;3.56,6.07,;3.56,7.61,;4.89,8.38,;2.23,8.38,;4.89,5.3,;6.23,6.07,;4.89,3.76,;6.23,2.99,;3.56,2.99,;3.56,1.45,;4.89,.68,;2.23,3.76,;.89,2.99,;.89,1.45,)|
Structure:
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Substrate
Name:
BDBM23230
Synonyms:
2-Oxosuccinic acid | 2-oxobutanedioic acid | Oxaloacetate | Oxaloacetic acid | keto-Oxaloacetate
Type:
Small organic molecule
Emp. Form.:
C4H4O5
Mol. Mass.:
132.0716
SMILES:
OC(=O)CC(=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: