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Target
MAP kinase-interacting serine/threonine-protein kinase 2
Ligand
BDBM181530
Substrate
n/a
Meas. Tech.
MNK2a In Vitro Kinase Assay 2
Temperature
298.15±n/a K
IC50
1.000±n/a nM
Comments
extracted
Citation
 Blum, A; Gottschling, D; Heckel, A; Hehn, JP; Schmid, B; Wiedenmayer, D Sulfoximine substituted quinazolines for pharmaceutical compositions US Patent  US9708274 Publication Date 7/18/2017 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 2
Synonyms:
GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2
Type:
Protein
Mol. Mass.:
51870.79
Organism:
Homo sapiens (Human)
Description:
Q9HBH9
Residue:
465
Sequence:
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
  
Inhibitor
Name:
BDBM181530
Synonyms:
US9139577, 4.036 | US9708274, 4.036
Type:
Small organic molecule
Emp. Form.:
C22H24F3N5O3S
Mol. Mass.:
495.518
SMILES:
C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O)C(=O)NCC(F)F |r|
Structure:
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