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Target
Alpha-glucosidase MAL32
Ligand
BDBM23842
Substrate
BDBM23837
Meas. Tech.
alpha-Glucosidase Inhibition Assay
pH
7±n/a
Temperature
310.15±n/a K
IC50
8000±n/a nM
Citation
 Dodo, K; Aoyama, A; Noguchi-Yachide, T; Makishima, M; Miyachi, H; Hashimoto, Y Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem 16:4272-85 (2008) [PubMed]  Article 
Target
Name:
Alpha-glucosidase MAL32
Synonyms:
Alpha-glucosidase MAL32 | MAL32 | MAL32_YEAST | MAL3S | Maltase | alpha-Glucosidase (α-Glucosidase) | alpha-Glucosidase (alpha-Glu) | alpha-Glucosidase (α-Glucosidase)
Type:
Hydrolase
Mol. Mass.:
68132.36
Organism:
Saccharomyces cerevisiae
Description:
Purchased from Wako Fine Chemicals Co. Ltd.
Residue:
584
Sequence:
MTISDHPETEPKWWKEATIYQIYPASFKDSNNDGWGDLKGITSKLQYIKDLGVDAIWVCPFYDSPQQDMGYDISNYEKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSFFGGSAWTFDETTNEFYLRLFASRQVDLNWENEDCRRAIFESAVGFWLDHGVDGFRIDTAGLYSKRPGLPDSPIFDKTSKLQHPNWGSHNGPRIHEYHQELHRFMKNRVKDGREIMTVGEVAHGSDNALYTSAARYEVSEVFSFTHVELGTSPFFRYNIVPFTLKQWKEAIASNFLFINGTDSWATTYIENHDQARSITRFADDSPKYRKISGKLLTLLECSLTGTLYVYQGQEIGQINFKEWPIEKYEDVDVKNNYEIIKKSFGKNSKEMKDFFKGIALLSRDHSRTPMPWTKDKPNAGFTGPDVKPWFFLNESFEQGINVEQESRDDDSVLNFWKRALQARKKYKELMIYGYDFQFIDLDSDQIFSFTKEYEDKTLFAALNFSGEEIEFSLPREGASLSFILGNYDDTDVSSRVLKPWEGRIYLVK
  
Inhibitor
Name:
BDBM23842
Synonyms:
2-[2,6-bis(propan-2-yl)phenyl]-3-sulfanylidene-2,3-dihydro-1H-isoindol-1-one | CHEMBL329471 | PPS-33
Type:
Small organic molecule
Emp. Form.:
C20H21NOS
Mol. Mass.:
323.452
SMILES:
CC(C)c1cccc(C(C)C)c1N1C(=O)c2ccccc2C1=S
Structure:
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Substrate
Name:
BDBM23837
Synonyms:
(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-nitrophenoxy)oxane-3,4,5-triol | 4-nitrophenyl alpha-glucoside | p-NPG | p-Nitrophenyl alpha-D-glucopyranoside | pNPG
Type:
Chromogenic substrate
Emp. Form.:
C12H15NO8
Mol. Mass.:
301.2494
SMILES:
OC[C@H]1O[C@H](Oc2ccc(cc2)[N+]([O-])=O)[C@H](O)[C@@H](O)[C@@H]1O
Structure:
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