Reaction Details Report a problem with these data
Target
Epidermal growth factor receptor [696-1022,G719S]
Ligand
BDBM26105
Substrate
BDBM10852
Meas. Tech.
Fluorescence Binding Assay
pH
7.4±n/a
Temperature
295.15±n/a K
Kd
11.3±1.5 nM
Citation
Yun, CH; Boggon, TJ; Li, Y; Woo, MS; Greulich, H; Meyerson, M; Eck, MJ Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity. Cancer Cell 11:217-27 (2007) [PubMed] Article
More Info.:
Target
Name:
Epidermal growth factor receptor [696-1022,G719S]
Synonyms:
EGF-R Tyrosine Kinase Mutant (G719S) | EGFR | EGFR_HUMAN | ERBB | ERBB1 | HER1
Type:
Tyrosine-protein kinase
Mol. Mass.:
37282.74
Organism:
Homo sapiens (Human)
Description:
P00533[696-1022,G719S]
Residue:
327
Sequence:
GEAPNQALLRILKETEFKKIKVLSSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQG
Inhibitor
Name:
BDBM26105
Synonyms:
6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | AEE788
Type:
Small organic molecule
Emp. Form.:
C27H32N6
Mol. Mass.:
440.5832
SMILES:
CCN1CCN(Cc2ccc(cc2)-c2cc3c(N[C@H](C)c4ccccc4)ncnc3[nH]2)CC1 |r|
Substrate