Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM387049
Substrate
n/a
Meas. Tech.
In Vitro Assay
Ki
<10±n/a nM
Citation
 Ding, Z; Lai, G; Chen, S; Yan, X Hydrazine compound as blood coagulation factor Xa inhibitor US Patent  US9938272 Publication Date 4/10/2018 
Target
Name:
Coagulation factor X
Synonyms:
Coagulation factor X precursor | F10 | FA10_RAT | Factor Xa (fXa) | Stuart factor
Type:
Enzyme
Mol. Mass.:
54255.03
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
482
Sequence:
MESPVRLSLLYVVLASLLLPGRSVFINRERANNVLQRIRRANSFFEEIKKGNLERECVEEICSFEEAREVFEDNEKTTEFWNKYEDGDQCESSPCQNQGECRDGLGSYTCTCTEGFEGKNCELFVRKLCSLDNGDCDQFCREEQNSVVCSCAKGYFLGNDGKSCLSTAPFPCGKTNKGRAKRSVALNTSNSEPDPEDLMPDADILYPTESPSELLNLNKTEPEANSDDVIRIVGGQECKRGECPWQALLFSDEETDGFCGGTILNEFYILTAAHCLHQAKRFKVRVGDLNTEQEDGGEMVHEVDMIIKHNKFQRDTYDFDIAMLRLKTPITFRENVAPACLPQKDWAEATLMTQKTGIVSGFGRTHEKGRQSKVLKMMEVPYVDRNTCRLSTSFSITQNMFCAGYDAKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKARVGPTSETPRLTHPPY
  
Inhibitor
Name:
BDBM387049
Synonyms:
4-(4-(1-(4-Methoxyphenyl)-7-oxo-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridin-6(7H)-yl)piperidin-1-yl)morpholin-3-one | US9938272, Example 1
Type:
Small organic molecule
Emp. Form.:
C23H26F3N5O4
Mol. Mass.:
493.4788
SMILES:
COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Structure:
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