Reaction Details Report a problem with these data
Target
Aurora kinase B
Ligand
BDBM27078
Substrate
Biotinylated Cross-tide Substrate
Meas. Tech.
Aurora Kinase Assay
pH
8.5±n/a
Temperature
295.15±n/a K
IC50
180±n/a nM
Citation
Howard, S; Berdini, V; Boulstridge, JA; Carr, MG; Cross, DM; Curry, J; Devine, LA; Early, TR; Fazal, L; Gill, AL; Heathcote, M; Maman, S; Matthews, JE; McMenamin, RL; Navarro, EF; O'Brien, MA; O'Reilly, M; Rees, DC; Reule, M; Tisi, D; Williams, G; Vinković, M; Wyatt, PG Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity. J Med Chem 52:379-88 (2009) [PubMed] Article
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
Inhibitor
Name:
BDBM27078
Synonyms:
N-[3-(1H-1,3-benzodiazol-2-yl)-1H-pyrazol-4-yl]benzamide | pyrazole-benzimidazole amide analogue, 7
Type:
Small organic molecule
Emp. Form.:
C17H13N5O
Mol. Mass.:
303.318
SMILES:
O=C(Nc1c[nH]nc1-c1nc2ccccc2[nH]1)c1ccccc1
Substrate
Name:
Biotinylated Cross-tide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
2578.93
Organism:
n/a
Description:
n/a
Residue:
24
Sequence:
ITINCGPKGPGRRGRRRTSSFAEG