Target
Aurora kinase B
Ligand
BDBM27081
Substrate
Biotinylated Cross-tide Substrate
Meas. Tech.
Aurora Kinase Assay
pH
8.5±n/a
Temperature
295.15±n/a K
IC50
54±n/a nM
Citation
 Howard, SBerdini, VBoulstridge, JACarr, MGCross, DMCurry, JDevine, LAEarly, TRFazal, LGill, ALHeathcote, MMaman, SMatthews, JEMcMenamin, RLNavarro, EFO'Brien, MAO'Reilly, MRees, DCReule, MTisi, DWilliams, GVinković, MWyatt, PG Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity. J Med Chem 52:379-88 (2009) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM27081
Synonyms:
3-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-2-yl]-1H-pyrazol-4-yl}-1-phenylurea | pyrazole-benzimidazole urea analogue, 10
Type:
Small organic molecule
Emp. Form.:
C22H23N7O2
Mol. Mass.:
417.4637
SMILES:
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)Nc1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Biotinylated Cross-tide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
2578.93
Organism:
n/a
Description:
n/a
Residue:
24
Sequence:
ITINCGPKGPGRRGRRRTSSFAEG