Target
Histone deacetylase 8
Ligand
BDBM19149
Substrate
Fluor de Lys-HDAC8 Fluorogenic Deacetylase Substrate
Meas. Tech.
HDAC Activity Assay
Temperature
298.15±n/a K
IC50
1860±n/a nM
Comments
extracted
Citation
 Oyelere, AKChen, PCGuerrant, WMwakwari, SCHood, RZhang, YFan, Y Non-peptide macrocyclic histone deacetylase inhibitors. J Med Chem 52:456-68 (2009) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM19149
Synonyms:
CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA | US10011611, SAHA | US10188756, Compound SAHA | US11207431, SAHA | US11505523, Compound SAHA | US9115116, SAHA | US9353061, SAHA | US9428447, SAHA | US9695181, Vorinostat | Vorinostat | Zolinza | cid_5311 | suberoylanilide hydroxamic acid
Type:
Small organic molecule
Emp. Form.:
C14H20N2O3
Mol. Mass.:
264.3202
SMILES:
ONC(=O)CCCCCCC(=O)Nc1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Fluor de Lys-HDAC8 Fluorogenic Deacetylase Substrate
Synonyms:
n/a
Type:
fluorogenic, diacetylated peptide
Mol. Mass.:
1716.47
Organism:
n/a
Description:
Residues 379-382 of p53.
Residue:
16
Sequence:
ARGHISLYSACLYSAC