Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetcAMP-Dependent Protein Kinase (PKA)
LigandBDBM27235
Substrate/CompetitorBDBM27221
Meas. Tech.Fluorescence Polarization-Based Binding Displacement Kinase Assay
pH7.5±n/a
Temperature303.15±n/a K
Kd 6050±520 nM
Citation Lavogina, DLust, MViil, IKönig, NRaidaru, GRogozina, JEnkvist, EUri, ABossemeyer, D Structural analysis of ARC-type inhibitor (ARC-1034) binding to protein kinase A catalytic subunit and rational design of bisubstrate analogue inhibitors of basophilic protein kinases. J Med Chem52:308-21 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
cAMP-Dependent Protein Kinase (PKA)
Name:cAMP-Dependent Protein Kinase (PKA)
Synonyms:PKA C-alpha | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase, alpha-catalytic subunit
Type:Enzyme Catalytic Unit
Mol. Mass.:40579.18
Organism:Mus musculus (mouse)
Description:n/a
Residue:351
Sequence:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVML
VKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM27235
NameBDBM27235
Synonyms:6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]formamido}-N-(3-aminopropyl)hexanamide | ARC-1007, 9
TypeSmall organic molecule
Emp. Form.C19H30N8O5
Mol. Mass.450.4921
SMILESNCCCNC(=O)CCCCCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
BDBM27221
NameBDBM27221
Synonyms:Adc-Ahx-(D-Arg)(6)-D-Lys(5-TAMRA)-NH2 | Fluorescent probe ARC-583
Type5-TAMRA labeled compound
Emp. Form.n/a
Mol. Mass.n/a
SMILESn/a
Structure