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Target
Baculoviral IAP repeat-containing protein 2 [266-354]
Ligand
BDBM27919
Substrate
BDBM17342
Meas. Tech.
Fluorescence Polarization Affinity Measurements
Ki
33±n/a nM
Citation
Cohen, F; Alicke, B; Elliott, LO; Flygare, JA; Goncharov, T; Keteltas, SF; Franklin, MC; Frankovitz, S; Stephan, JP; Tsui, V; Vucic, D; Wong, H; Fairbrother, WJ Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold. J Med Chem 52:1723-30 (2009) [PubMed] Article
More Info.:
Target
Name:
Baculoviral IAP repeat-containing protein 2 [266-354]
Synonyms:
API1 | BIRC2 | BIRC2_HUMAN | Chimeric protein of inhibitor of apoptosis protein 2-baculovirus IAP repeat 3 (BIR3) | MIHB | RNF48 | cIAP1-BIR3 | cIAP1-BIR3/XIAP-BIR3 chimeric protein | cIAP1XBIR3
Type:
Chimeric Protein
Mol. Mass.:
10496.31
Organism:
Homo sapiens (Human)
Description:
Q13490[266-354]
Residue:
89
Sequence:
MQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPH
Inhibitor
Name:
BDBM27919
Synonyms:
Azabicyclooctane scaffold, 14b | N-[(3aR,6S,6aS)-1-[(2S)-3,3-dimethyl-2-[(2S)-2-(methylamino)propanamido]butanoyl]-octahydrocyclopenta[b]pyrrol-6-yl]naphthalene-1-carboxamide
Type:
Small organic molecule
Emp. Form.:
C28H38N4O3
Mol. Mass.:
478.6263
SMILES:
[H][C@]12CC[C@H](NC(=O)c3cccc4ccccc34)[C@@]1([H])N(CC2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C |r|