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Target
5-hydroxytryptamine receptor 1D
Ligand
BDBM28574
Substrate
BDBM10755
Meas. Tech.
Radioligand Binding Assay (Ki)
pH
7.4±n/a
Temperature
295.15±n/a K
Ki
>2000±n/a nM
Citation
 Liu, KG; Lo, JR; Comery, TA; Zhang, GM; Zhang, JY; Kowal, DM; Smith, DL; Di, L; Kerns, EH; Schechter, LE; Robichaud, AJ 1-Sulfonylindazoles as potent and selective 5-HT6 ligands. Bioorg Med Chem Lett 19:2413-5 (2009) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1D
Synonyms:
5-HT-1D | 5-HT-1D-alpha | 5-HT1D | 5-hydroxytryptamine receptor 1D (5-HT1D) | 5HT1D_HUMAN | HTR1D | HTR1DA | HTRL | Serotonin (5-HT) receptor | Serotonin Receptor 1D
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41920.63
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
377
Sequence:
MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
  
Inhibitor
Name:
BDBM28574
Synonyms:
1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene-1-sulfonyl)-1H-indazol-6-yl]propanamide
Type:
Small organic molecule
Emp. Form.:
C20H18N4O3S
Mol. Mass.:
394.447
SMILES:
NCCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM10755
Synonyms:
14C-5-hydroxy tryptamine creatinine disulfate | 2-imino-1-methylimidazolidin-4-one; 3-(2-aminoethyl)-1H-indol-5-ol; bis(sulfuric acid) | 5-HT | 5-Hydroxy Tryptamine | 5-hydroxy tryptamine creatinine disulfate | CHEMBL535832 | Serotonin | [3H]-5-HT
Type:
Small organic molecule
Emp. Form.:
C10H12N2O
Mol. Mass.:
176.2151
SMILES:
NCCc1c[nH]c2ccc(O)cc12
Structure:
Search PDB for entries with ligand similarity: