Target

Ligand

Substrate

Meas. Tech.

Enzyme Inhibition Assay

pH

7.4±n/a

Temperature

310.15±n/a K

Citation

 Chu, W; Rothfuss, J; Chu, Y; Zhou, D; Mach, RH Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. J Med Chem 52:2188-91 (2009) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method

Name:

Caspase-1

Synonyms:

CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme

Type:

Enzyme

Mol. Mass.:

45154.13

Organism:

Homo sapiens (Human)

Description:

P29466

Residue:

404

Sequence:

MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM10355

Synonyms:

(3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-4-oxobutanoic acid | Ac-YVAD-CHO | CHEMBL37630

Type:

Small organic molecule

Emp. Form.:

C23H32N4O8

Mol. Mass.:

492.5222

SMILES:

CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C=O |r|

Structure:

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Similarity to this molecule at least:

Name:

Caspase-1 Substrate

Synonyms:

N-acetyl-Tyr-Val-Ala-Asp-AMC (7-amino-4-methylcoumarin)

Type:

Fluorogenic Substrate

Mol. Mass.:

945.11

Organism:

n/a

Description:

n/a

Residue:

9

Sequence:

ACYVADAMC