Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM31206
Substrate
PMDM6-F Peptide
Meas. Tech.
Fluorescence Polarization-Based (FP-Based) Binding Assay
pH
7.5±n/a
Temperature
296.15±n/a K
Ki
120±30 nM
Citation
Lu, Y; Nikolovska-Coleska, Z; Fang, X; Gao, W; Shangary, S; Qiu, S; Qin, D; Wang, S Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J Med Chem 49:3759-62 (2006) [PubMed] Article
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
Inhibitor
Name:
BDBM31206
Synonyms:
NSC 66811
Type:
Small organic molecule
Emp. Form.:
C23H20N2O
Mol. Mass.:
340.4177
SMILES:
Cc1ccc2ccc(C(Nc3ccccc3)c3ccccc3)c(O)c2n1
Substrate
Name:
PMDM6-F Peptide
Synonyms:
n/a
Type:
Fluorescence probe
Mol. Mass.:
4802.47
Organism:
n/a
Description:
n/a
Residue:
45
Sequence:
FAMETAALAETAALAPHEMETAIPTYRCLLTRPGLACCLEASNNH