Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM31305
Substrate
Fl 9mer
Meas. Tech.
Fluorescent Peptide Displacement Assay
pH
7.4±n/a
Temperature
296.15±n/a K
IC50
856±n/a nM
Citation
 Marugan, JJLeonard, KRaboisson, PGushue, JMCalvo, RKoblish, HKLattanze, JZhao, SCummings, MDPlayer, MRSchubert, CMaroney, ACLu, T Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists. Bioorg Med Chem Lett 16:3115-20 (2006) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM31305
Synonyms:
1,4-benzodiazepine-2,5-dione, 12b | BMCL163310 Compound 19
Type:
Small organic molecule
Emp. Form.:
C28H25Cl2IN2O4
Mol. Mass.:
651.32
SMILES:
C[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCCCC(O)=O)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Fl 9mer
Synonyms:
n/a
Type:
fluorescent peptide
Mol. Mass.:
2263.48
Organism:
n/a
Description:
n/a
Residue:
18
Sequence:
FLRESCEINFMDYWEGLN