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Target
Bcl-2-like protein 1
Ligand
BDBM31389
Substrate
Fl-Bak peptide
Meas. Tech.
Fluorescence Polarization Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Comments
No affinity.
Citation
 Yin, H; Lee, GI; Sedey, KA; Rodriguez, JM; Wang, HG; Sebti, SM; Hamilton, AD Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction. J Am Chem Soc 127:5463-8 (2005) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM31389
Synonyms:
CHEMBL29180 | terephthalamide scaffold, 36
Type:
Small organic molecule
Emp. Form.:
C13H16N2O4
Mol. Mass.:
264.2771
SMILES:
COC(=O)CNC(=O)c1ccc(cc1)C(=O)N(C)C
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Fl-Bak peptide
Synonyms:
n/a
Type:
Fluoroscein-labled peptide
Mol. Mass.:
2079.80
Organism:
n/a
Description:
The N-terminus of fluoroscein-labled Bak peptide was capped with the fluorophore and the C-terminus was amidated.
Residue:
19
Sequence:
GQVGRQLAIIGDDINRCNH