Target
Dimer of Gag-Pol polyprotein [489-587,I573V]
Ligand
BDBM517
Substrate
HIV-1 Protease substrate
Meas. Tech.
Protease Inhibition Assay
pH
5.5±n/a
Temperature
303.15±n/a K
Ki
3.107±0.393 nM
Comments
kcat/Km=3.16/sec/mM
Citation
 Vacca, JPDorsey, BDSchleif, WALevin, RBMcDaniel, SLDarke, PLZugay, JQuintero, JCBlahy, OMRoth, E L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor. Proc Natl Acad Sci U S A 91:4096-100 (1994) [PubMed]  Article 
Target
Name:
Dimer of Gag-Pol polyprotein [489-587,I573V]
Synonyms:
HIV-1 Protease Mutant (I84V)
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Gag-Pol polyprotein [489-587,I573V]
Synonyms:
HIV-1 Protease Mutant (I84V) chain A | HIV-1 Protease Mutant (I84V) chain B | POL_HV1H2 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10767.13
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587,I573V]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNVIGRNLLTQIGCTLNF
  
Component 2
Name:
Gag-Pol polyprotein [489-587,I573V]
Synonyms:
HIV-1 Protease Mutant (I84V) chain A | HIV-1 Protease Mutant (I84V) chain B | POL_HV1H2 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10767.13
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587,I573V]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNVIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM517
Synonyms:
(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamoyl}butyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide | CHEMBL115 | Crixivan | INDINAVIR SULFATE | Indinavir | Indinavir, 19 | L-735, 524 | MK639
Type:
Small organic molecule
Emp. Form.:
C36H47N5O4
Mol. Mass.:
613.7895
SMILES:
CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12 |@:19,@@:9|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
HIV-1 Protease substrate
Synonyms:
HIV Protease Peptide Substrate
Type:
Peptide
Mol. Mass.:
4082.51
Organism:
n/a
Description:
n/a
Residue:
38
Sequence:
VALSERGLNASNETANAPHTHYLALANINEPRILEVAL