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TargetHeat shock protein HSP 90-alpha
LigandBDBM32185
Substrate/Competitorcy3B-GM
Meas. Tech.Tumor Hsp90 Inhibitors Dose Response Confirmation
pH7.4±n/a
Temperature296.15±n/a K
IC50 50000±n/a nM
Citation PubChem, PC Tumor Hsp90 Inhibitors Dose Response Confirmation PubChem Bioassay(2007)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Heat shock protein HSP 90-alpha
Name:Heat shock protein HSP90
Synonyms:HSP 86 | HSP86 | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat Shock Protein 90 (Hsp90) | Heat shock 86 kDa | Heat shock protein HSP 90 (HSP90) | Heat shock protein HSP 90-alpha (HSP90) | Heat shock protein HSP 90-alpha (HSP90A) | LAP-2 | LPS-associated protein 2 | Lipopolysaccharide-associated protein 2 | Renal carcinoma antigen NY-REN-38 | heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2
Type:Molecular Chaperone
Mol. Mass.:84623.45
Organism:Homo sapiens (Human)
Description:n/a
Residue:732
Sequence:
MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIR
YESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFME
ALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPM
GRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKED
KEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRN
PDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNN
IKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKC
LELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDY
CTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKT
LVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIV
TSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVK
DLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLE
GDDDTSRMEEVD
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BDBM32185
NameBDBM32185
Synonyms:6-[5-(3-methoxy-4-oxidanyl-phenyl)pyrazolidin-3-ylidene]cyclohexa-2,4-dien-1-one | 6-[5-(4-hydroxy-3-methoxy-phenyl)pyrazolidin-3-ylidene]cyclohexa-2,4-dien-1-one | 6-[5-(4-hydroxy-3-methoxyphenyl)-3-pyrazolidinylidene]-1-cyclohexa-2,4-dienone | 6-[5-(4-hydroxy-3-methoxyphenyl)pyrazolidin-3-ylidene]cyclohexa-2,4-dien-1-one | CHEMBL210638 | TG2-101-2 | cid_6790395
TypeSmall organic molecule
Emp. Form.C16H16N2O3
Mol. Mass.284.3098
SMILESCOc1cc(ccc1O)C1CC(N=N1)c1ccccc1O |c:13|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
cy3B-GM
Name:cy3B-GM
Synonyms:fluorescently (Cy3B) labeled geldanamycin
Type:fluorescent probe
Mol. Mass.:358.43
Organism:n/a
Description:n/a
Residue:3
Sequence:
n/a