Target
11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S]
Ligand
BDBM32566
Substrate
BDBM13739
Meas. Tech.
Human 11beta-HSD1 SPA Assay
IC50
3±n/a nM
EC50
315±n/a nM
Citation
 Sun, DWang, ZDi, YJaen, JCLabelle, MMa, JMiao, SSudom, ATang, LTomooka, CSTu, HUrsu, SWalker, NYan, XYe, QPowers, JP Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). Bioorg Med Chem Lett 18:3513-6 (2008) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S]
Synonyms:
11-DH | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Homodimer
Mol. Mass.:
31804.08
Organism:
Homo sapiens (Human)
Description:
Purified recombinant human 11beta-HSD1.
Residue:
286
Sequence:
MKHQHQHQHQHQHQQPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM32566
Synonyms:
arylsulfonylpiperazine, 38
Type:
Small organic molecule
Emp. Form.:
C21H26F3N3O2S
Mol. Mass.:
441.51
SMILES:
CC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCCN(CC1)c1ncccc1C(F)(F)F
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM13739
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-5,17-dione | [3H]-cortisone | [3H]cortisone | cortisone
Type:
Steroid
Emp. Form.:
C21H28O5
Mol. Mass.:
360.444
SMILES:
[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)CC(=O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C |t:23|
Structure:
Search PDB for entries with ligand similarity: