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Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM209476
Substrate
n/a
Meas. Tech.
BRD4-H4 Tetraacetylated Peptide Inhibition AlphaScreen
IC50
17.0±n/a nM
Citation
 Engelhardt, H; Gianni, D; Smethurst, C Substituted [1,2,4]triazolo[4,3-a]pyrazines as BRD4 inhibitors US Patent  US10328074 Publication Date 6/25/2019 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM209476
Synonyms:
US10328074, Example III-17 | US11077107, Example III-17 | US9266891, III-17
Type:
Small organic molecule
Emp. Form.:
C26H30N10
Mol. Mass.:
482.5834
SMILES:
CCNc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccccc1)N1CCN(C)CC1
Structure:
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