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TargetGlycogen Phosphorylase (PYGM)
LigandBDBM34108
Substrate/CompetitorBDBM23188
Meas. Tech.Enzyme Inhibition Assay
pH6.8±n/a
Temperature303.15±n/a K
Ki 19600±200 nM
Citation Benltifa, MHayes, JMVidal, SGueyrard, DGoekjian, PGPraly, JPKizilis, GTiraidis, CAlexacou, KMChrysina, EDZographos, SELeonidas, DDArchontis, GOikonomakos, NG Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors. Bioorg Med Chem17:7368-80 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Glycogen Phosphorylase (PYGM)
Name:Glycogen phosphorylase, muscle form
Synonyms:Glycogen Phosphorylase (PYGM) | Glycogen phosphorylase a (RMGPa) | Myophosphorylase
Type:Enzyme
Mol. Mass.:97296.32
Organism:Oryctolagus cuniculus (rabbit)
Description:Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.
Residue:843
Sequence:
MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTV
RDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDM
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEA
DDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVN
TMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERL
DWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFP
GDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKF
QNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQ
ENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVV
PRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPA
ADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVD
RLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEE
YVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE
KIP
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BDBM34108
NameBDBM34108
Synonyms:glucopyranosylidene-spiro-isoxazoline, 4c
TypeSmall organic molecule
Emp. Form.C14H17NO6
Mol. Mass.295.2879
SMILESOC[C@H]1O[C@@]2(CC(=NO2)c2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O |c:6|
Structure
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BDBM23188
NameBDBM23188
Synonyms:alpha-glucose-1-phosphate | cori ester | glucose-1-phosphate | {[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phosphonic acid
Typen/a
Emp. Form.C6H13O9P
Mol. Mass.260.1358
SMILESOC[C@H]1O[C@H](OP(O)(O)=O)[C@H](O)[C@@H](O)[C@@H]1O
Structure
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