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Target
Glycogen phosphorylase, muscle form
Ligand
BDBM34110
Substrate
BDBM23188
Meas. Tech.
Enzyme Inhibition Assay
pH
6.8±n/a
Temperature
303.15±n/a K
Ki
630±20 nM
Citation
 Benltifa, M; Hayes, JM; Vidal, S; Gueyrard, D; Goekjian, PG; Praly, JP; Kizilis, G; Tiraidis, C; Alexacou, KM; Chrysina, ED; Zographos, SE; Leonidas, DD; Archontis, G; Oikonomakos, NG Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors. Bioorg Med Chem 17:7368-80 (2009) [PubMed]  Article 
Target
Name:
Glycogen phosphorylase, muscle form
Synonyms:
Glycogen Phosphorylase (PYGM) | Glycogen phosphorylase a (RMGPa) | Glycogen phosphorylase, muscle form | Myophosphorylase | PYGM | PYGM_RABIT
Type:
Enzyme
Mol. Mass.:
97296.32
Organism:
Oryctolagus cuniculus (rabbit)
Description:
Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.
Residue:
843
Sequence:
MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERLDWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVVPRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDRLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEKIP
  
Inhibitor
Name:
BDBM34110
Synonyms:
glucopyranosylidene-spiro-isoxazoline, 4e
Type:
Small organic molecule
Emp. Form.:
C18H19NO6
Mol. Mass.:
345.3466
SMILES:
OC[C@H]1O[C@@]2(CC(=NO2)c2ccc3ccccc3c2)[C@H](O)[C@@H](O)[C@@H]1O |c:6|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23188
Synonyms:
alpha-glucose-1-phosphate | cori ester | glucose-1-phosphate | {[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phosphonic acid
Type:
n/a
Emp. Form.:
C6H13O9P
Mol. Mass.:
260.1358
SMILES:
OC[C@H]1O[C@H](OP(O)(O)=O)[C@H](O)[C@@H](O)[C@@H]1O
Structure:
Search PDB for entries with ligand similarity: