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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM35039
Substrate
Biotinylated Substrate Peptide
Meas. Tech.
Pim Kinase Assay
Temperature
298.15±n/a K
Ki
5±n/a nM
Comments
extracted
Citation
 Tao, ZF; Hasvold, LA; Leverson, JD; Han, EK; Guan, R; Johnson, EF; Stoll, VS; Stewart, KD; Stamper, G; Soni, N; Bouska, JJ; Luo, Y; Sowin, TJ; Lin, NH; Giranda, VS; Rosenberg, SH; Penning, TD Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases. J Med Chem 52:6621-36 (2009) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM35039
Synonyms:
benzothienopyrimidinone deriv., 17a
Type:
Small organic molecule
Emp. Form.:
C17H20N4OS
Mol. Mass.:
328.432
SMILES:
CN(C)Cc1nc2c3cc(ccc3sc2c(=O)[nH]1)N1CCCC1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Ryanodine receptor 1 [4317-4329]
Synonyms:
Biotinylated Substrate Peptide | RYDR | RYR1 | RYR1_HUMAN
Type:
Peptide
Mol. Mass.:
2871.44
Organism:
n/a
Description:
P21817[4317-4329]
Residue:
24
Sequence:
ITINCLINKERVRRLRRLTAREAA