Target
Neutrophil elastase
Ligand
BDBM35265
Substrate
BDBM35258
Meas. Tech.
Neutrophil Elastase (HNE) Inhibition Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
42±n/a nM
Citation
 Inoue, YOmodani, TShiratake, ROkazaki, HKuromiya, AKubo, TSato, F Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury. Bioorg Med Chem 17:7477-86 (2009) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM35265
Synonyms:
tripeptide-based inhibitor, 14h
Type:
Small organic molecule
Emp. Form.:
C29H36N6O9
Mol. Mass.:
612.6309
SMILES:
CC(C)[C@H](NC(=O)Cn1cc(O)n(CC(O)=O)c1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)c1nc2ccccc2o1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM35258
Synonyms:
Suc-Ala-Pro-Ala-MCA
Type:
fluorogenic substrate
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: