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Target
Kinesin-like protein KIF11 [A356T]
Ligand
BDBM36350
Substrate
n/a
Meas. Tech.
WT-6x
pH
6.8±0
Ki
66±5 nM
Citation
 Luo, L; Parrish, CA; Nevins, N; McNulty, DE; Chaudhari, AM; Carson, JD; Sudakin, V; Shaw, AN; Lehr, R; Zhao, H; Sweitzer, S; Lad, L; Wood, KW; Sakowicz, R; Annan, RS; Huang, PS; Jackson, JR; Dhanak, D; Copeland, RA; Auger, KR ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism. Nat Chem Biol 3:722-6 (2007) [PubMed]  Article 
Target
Name:
Kinesin-like protein KIF11 [A356T]
Synonyms:
EG5 | KIF11 | KIF11_HUMAN | KNSL1 | KSP Mutant (A356T) | TRIP5 | kinesin spindle protein Mutant (A356T)
Type:
PROTEIN
Mol. Mass.:
119168.99
Organism:
Homo sapiens (Human)
Description:
Kinesin-like spindle protein HKSP, Kinesin-related motor protein Eg5 (A356T)
Residue:
1056
Sequence:
MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRTKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKTSLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNEREQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNETIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLMMLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGKDKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
  
Inhibitor
Name:
BDBM36350
Synonyms:
6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-quinolinone | CID12000936 | GSK-1
Type:
Small organic molecule
Emp. Form.:
C16H12F3NO
Mol. Mass.:
291.2678
SMILES:
FC(F)(F)c1ccc(cc1)-c1ccc2NC(=O)CCc2c1
Structure:
Search PDB for entries with ligand similarity: