Target
Receptor protein serine/threonine kinase
Ligand
BDBM5416
Substrate
poly(Glu4, Tyr)
Meas. Tech.
Kinase assay intersomitic vessel (ISV) disruption
EC50
5e+3±n/a nM
Citation
 Hao, JHo, JNLewis, JAKarim, KADaniels, RNGentry, PRHopkins, CRLindsley, CWHong, CC In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem Biol 5:245-53 (2010) [PubMed]  Article 
Target
Name:
Receptor protein serine/threonine kinase
Synonyms:
B3DJG0 | BMP | Bmpr1a protein | Bone morphogenetic protein
Type:
n/a
Mol. Mass.:
59502.00
Organism:
Danio rerio (Zebrafish)
Description:
B3DJG0
Residue:
526
Sequence:
MRQLLFITVVLTGVCLLLTLCSGGQNPDHVLQGTGVKLDSRRPGDDSTIAPEDAARFLSCHCSGHCPDDAKNNTCETNGQCFAIIEEDENGDVILSSGCMKYEGSHFQCKDSQFAQTRRTIECCQFDFCNQDLKPELPPRDSEPPDPHWLAFLISVTVCFCALICVTVICYYRYKWQTERQRYHRDLEQDEAFIPAGESLKDLINQSQTSGSGSGLPLLVQRTIAKQIQTVRMIGKGRYGEVWLGRWRGEKVAVKVFFTREEASWFRETEIYQTVLMRHENILGFIAADINGTGASTQLYLITDYHENGSLYDYLKFTTLDTQALLRLAFSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGTCCIADLGLAVKFNSDTNEVDLPLSTRMGTRRYMAPEVLDETLNKNHFQAYIMADIYSYGLVIWEMARRCVTGGIVEEYQLPYYEMVPSDPSYEDMLEVVCVKGLRPTVSNRWNSDECLRAMLKLMSECWAHNPASRLTILRVKKTLAKMVESQDIKI
  
Inhibitor
Name:
BDBM5416
Synonyms:
4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl]phenoxy}ethyl)morpholine | CHEMBL324153 | dorsomorphin (6K1) | pyrazolo[1,5-a]pyrimidine 4h
Type:
Small organic molecule
Emp. Form.:
C23H23N5O2
Mol. Mass.:
401.461
SMILES:
C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
poly(Glu4, Tyr)
Synonyms:
n/a
Type:
Random copolymer
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA