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Target
Kaposi's sarcoma-associated herpesvirus cyclin homolog
Ligand
BDBM36461
Substrate
n/a
Meas. Tech.
KSHV Pr Inhibition Assay
pH
8±0
Temperature
303.15±0 K
IC50
16.4±0.7 nM
Citation
Shahian, T; Lee, GM; Lazic, A; Arnold, LA; Velusamy, P; Roels, CM; Guy, RK; Craik, CS Inhibition of a viral enzyme by a small-molecule dimer disruptor. Nat Chem Biol 5:640-6 (2009) [PubMed] Article
More Info.:
Target
Name:
Kaposi's sarcoma-associated herpesvirus cyclin homolog
Synonyms:
Kaposi's sarcoma-associated herpesvirus (KSHV)
Type:
Enzyme
Mol. Mass.:
28080.00
Organism:
Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Description:
Q98147
Residue:
257
Sequence:
MATANNPPSGLLDPTLCEDRIFYNILEIEPRFLTSDSVFGTFQQSLTSHMRKLLGTWMFSVCQEYNLEPNVVALALNLLDRLLLIKQVSKEHFQKTGSACLLVASKLRSLTPISTSSLCYAAADSFSRQELIDQEKELLEKLAWRTEAVLATDVTSFLLLKLVGGSQHLDFWHHEVNTLITKALVDPKTGSLPASIISAAGCALLVPANVIPQDTHSGGVVPQLASILGCDVSVLQAAVEQILTSVSDFDLRILDSY