Target
Kaposi's sarcoma-associated herpesvirus cyclin homolog
Ligand
BDBM36461
Substrate
n/a
Meas. Tech.
KSHV Pr Inhibition Assay
pH
8±0
Temperature
303.15±0 K
IC50
16.4±0.7 nM
Citation
 Shahian, TLee, GMLazic, AArnold, LAVelusamy, PRoels, CMGuy, RKCraik, CS Inhibition of a viral enzyme by a small-molecule dimer disruptor. Nat Chem Biol 5:640-6 (2009) [PubMed]  Article 
Target
Name:
Kaposi's sarcoma-associated herpesvirus cyclin homolog
Synonyms:
Kaposi's sarcoma-associated herpesvirus (KSHV)
Type:
Enzyme
Mol. Mass.:
28080.00
Organism:
Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Description:
Q98147
Residue:
257
Sequence:
MATANNPPSGLLDPTLCEDRIFYNILEIEPRFLTSDSVFGTFQQSLTSHMRKLLGTWMFSVCQEYNLEPNVVALALNLLDRLLLIKQVSKEHFQKTGSACLLVASKLRSLTPISTSSLCYAAADSFSRQELIDQEKELLEKLAWRTEAVLATDVTSFLLLKLVGGSQHLDFWHHEVNTLITKALVDPKTGSLPASIISAAGCALLVPANVIPQDTHSGGVVPQLASILGCDVSVLQAAVEQILTSVSDFDLRILDSY
  
Inhibitor
Name:
BDBM36461
Synonyms:
3-Benzyl-4-(3-(cyclohexylmethyl)-4-methoxybenzamido)benzoic acid, 3 | CID42628633
Type:
Small organic molecule
Emp. Form.:
C29H31NO4
Mol. Mass.:
457.5607
SMILES:
COc1ccc(cc1CC1CCCCC1)C(=O)Nc1ccc(cc1Cc1ccccc1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: