Target
S-methyl-5'-thioadenosine phosphorylase
Ligand
BDBM22113
Substrate
BDBM22111
Meas. Tech.
Enzyme Activity Assay
pH
7.5±0
Temperature
298.15±0 K
Kd
0.034±0.0 nM
Citation
 Gutierrez, JALuo, MSingh, VLi, LBrown, RLNorris, GEEvans, GBFurneaux, RHTyler, PCPainter, GFLenz, DHSchramm, VL Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. ACS Chem Biol 2:725-34 (2007) [PubMed]  Article 
Target
Name:
S-methyl-5'-thioadenosine phosphorylase
Synonyms:
5'-Methylthioadenosine phosphorylase (MTAP) | MSAP | MTA phosphorylase | MTAP | MTAP_HUMAN | MTAPase | Methylthioadenosine Phosphorylase (MTAP) | S-methyl-5 -thioadenosine phosphorylase
Type:
Enzyme
Mol. Mass.:
31239.23
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
283
Sequence:
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
  
Inhibitor
Name:
BDBM22113
Synonyms:
(3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methyl)-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol | (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol | (3R,4S)-1-[(9-Deazaadenin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine, 7 | DADMe-ImmA-Me | MT-DADMe-ImmA
Type:
n/a
Emp. Form.:
C13H19N5OS
Mol. Mass.:
293.388
SMILES:
CSC[C@H]1CN(Cc2c[nH]c3c(N)ncnc23)C[C@@H]1O |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM22111
Synonyms:
(2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methylsulfanyl)methyl]oxolane-3,4-diol | (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol | 5'-Methylthioado | 5-methylthioadenosine | CHEMBL277041 | MTA
Type:
Nucleoside or nucleotide
Emp. Form.:
C11H15N5O3S
Mol. Mass.:
297.334
SMILES:
CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Structure:
Search PDB for entries with ligand similarity: