Target
HIV-1 protease
Ligand
BDBM36659
Substrate
n/a
Meas. Tech.
Protease Inhibtion Assay
pH
5.5±0
Ki
0.13±0.0 nM
Citation
 Rodgers, JDLam, PYJohnson, BLWang, HLi, RRu, YKo, SSSeitz, SPTrainor, GLAnderson, PSKlabe, RMBacheler, LTCordova, BGarber, SReid, CWright, MRChang, CHErickson-Viitanen, S Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors. Chem Biol 5:597-608 (1998) [PubMed]  Article 
Target
Name:
HIV-1 protease
Synonyms:
HIV-1 protease wild type
Type:
Protein
Mol. Mass.:
10757.68
Organism:
Human immunodeficiency virus
Description:
O90785
Residue:
99
Sequence:
PQITLWQRPLVTVKIGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYEQVLIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF
  
Inhibitor
Name:
BDBM36659
Synonyms:
n-Hexyl cyclic urea
Type:
Small organic molecule
Emp. Form.:
C33H41N5O3
Mol. Mass.:
555.7103
SMILES:
CCCCCCN1[C@H](Cc2ccccc2)[C@H](O)[C@@H](O)[C@@H](Cc2ccccc2)N(Cc2ccc3[nH]nc(N)c3c2)C1=O |r|
Structure:
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