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Target
Wee1-like protein kinase
Ligand
BDBM264273
Substrate
n/a
Meas. Tech.
Wee-1 kinase Assay
Temperature
298.15±n/a K
IC50
<10±n/a nM
Comments
extracted
Citation
 O Dowd, CR; Rountree, JS; Burkamp, F; Wilkinson, AJ Substituted pyrido[4,3-d]pyrimidines as Wee-1 inhibitors US Patent  US9714244 Publication Date 7/25/2017 
Target
Name:
Wee1-like protein kinase
Synonyms:
Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN
Type:
PROTEIN
Mol. Mass.:
71599.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1445054
Residue:
646
Sequence:
MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDSPLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFGSSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFRKLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
  
Inhibitor
Name:
BDBM264273
Synonyms:
2-((3-Chloro-4-(piperazin-1-yl)phenyl)amino)-6-(2,6-dichlorophenyl)pyrido[4,3-d]pyrimidin-5(6H)-one | US9714244, 27
Type:
Small organic molecule
Emp. Form.:
C23H19Cl3N6O
Mol. Mass.:
501.796
SMILES:
Clc1cccc(Cl)c1-n1ccc2nc(Nc3ccc(N4CCNCC4)c(Cl)c3)ncc2c1=O |(5.33,2.69,;6.67,1.92,;8,2.7,;9.34,1.92,;9.34,.38,;8,-.39,;8,-1.93,;6.67,.38,;5.33,-.39,;5.33,-1.93,;4,-2.7,;2.67,-1.93,;1.33,-2.7,;,-1.93,;-1.33,-2.7,;-2.67,-1.93,;-4,-2.7,;-5.33,-1.93,;-5.33,-.39,;-6.67,.38,;-8,-.39,;-9.34,.38,;-9.34,1.92,;-8,2.69,;-6.67,1.92,;-4,.38,;-4,1.92,;-2.67,-.39,;,-.39,;1.33,.39,;2.67,-.39,;4,.38,;4,1.92,)|
Structure:
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