Reaction Details Report a problem with these data
Target
fMet-Leu-Phe receptor
Ligand
BDBM37785
Substrate
n/a
Meas. Tech.
Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands
Ki
6300±n/a nM
Citation
 PubChem, PC Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands PubChem Bioassay (2007)[AID] 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM37785
Synonyms:
4-[(E)-[4,5-diketo-1-(3-morpholinopropyl)-2-(2-pyridyl)pyrrolidin-3-ylidene]-hydroxy-methyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid methyl ester | 4-[(E)-hydroxy-[1-[3-(4-morpholinyl)propyl]-4,5-dioxo-2-(2-pyridinyl)-3-pyrrolidinylidene]methyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid methyl ester | MLS000049366 | SMR000075274 | cid_5739108 | methyl 3,5-dimethyl-4-[(E)-[1-(3-morpholin-4-ylpropyl)-4,5-bis(oxidanylidene)-2-pyridin-2-yl-pyrrolidin-3-ylidene]-oxidanyl-methyl]-1H-pyrrole-2-carboxylate | methyl 4-[(E)-hydroxy-[1-(3-morpholin-4-ylpropyl)-4,5-dioxo-2-pyridin-2-ylpyrrolidin-3-ylidene]methyl]-3,5-dimethyl-1H-pyrrole-2-carboxylate | methyl 4-{[4-hydroxy-1-[3-(4-morpholinyl)propyl]-5-oxo-2-(2-pyridinyl)-2,5-dihydro-1H-pyrrol-3-yl]carbonyl}-3,5-dimethyl-1H-pyrrole-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C25H30N4O6
Mol. Mass.:
482.5289
SMILES:
COC(=O)c1[nH]c(C)c(C(=O)C2C(N(CCCN3CCOCC3)C(=O)C2=O)c2ccccn2)c1C
Structure:
Search PDB for entries with ligand similarity: