Reaction Details Report a problem with these data
Target
fMet-Leu-Phe receptor
Ligand
BDBM40420
Substrate
n/a
Meas. Tech.
Formylpeptide Receptor (FPR) Ligand Structure Activity Relationship (SAR) Analysis : Dose Response Assay
Ki
4700±n/a nM
Citation
 PubChem, PC Formylpeptide Receptor (FPR) Ligand Structure Activity Relationship (SAR) Analysis : Dose Response Assay PubChem Bioassay (2007)[AID] 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM40420
Synonyms:
1-(3-imidazol-1-ylpropyl)-2-(4-methoxyphenyl)-4-oxidanyl-3-thiophen-2-ylcarbonyl-2H-pyrrol-5-one | 3-hydroxy-1-(3-imidazol-1-ylpropyl)-5-(4-methoxyphenyl)-4-(2-thenoyl)-3-pyrrolin-2-one | 4-hydroxy-1-(3-imidazol-1-ylpropyl)-2-(4-methoxyphenyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one | 4-hydroxy-1-[3-(1-imidazolyl)propyl]-2-(4-methoxyphenyl)-3-[oxo(thiophen-2-yl)methyl]-2H-pyrrol-5-one | UNM000003552401 | cid_2907867
Type:
Small organic molecule
Emp. Form.:
C22H21N3O4S
Mol. Mass.:
423.485
SMILES:
COc1ccc(cc1)C1C(C(=O)c2cccs2)C(=O)C(=O)N1CCCn1ccnc1
Structure:
Search PDB for entries with ligand similarity: