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Target
Heat shock protein HSP 90-alpha
Ligand
BDBM32185
Substrate
n/a
Meas. Tech.
Cell-based secondary assay for identifying Hsp90 inhibitors that degrade Hsp90 client protein Her2
IC50
50970.5±n/a nM
Citation
 PubChem, PC Cell-based secondary assay for identifying Hsp90 inhibitors that degrade Hsp90 client protein Her2 PubChem Bioassay (2007)[AID] 
Target
Name:
Heat shock protein HSP 90-alpha
Synonyms:
HS90A_HUMAN | HSP 86 | HSP86 | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat Shock Protein 90 (Hsp90) | Heat shock 86 kDa | Heat shock protein HSP 90 (HSP90) | Heat shock protein HSP 90-alpha (HSP90) | Heat shock protein HSP 90-alpha (HSP90A) | LAP-2 | LPS-associated protein 2 | Lipopolysaccharide-associated protein 2 | Renal carcinoma antigen NY-REN-38 | heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2
Type:
Molecular Chaperone
Mol. Mass.:
84623.45
Organism:
Homo sapiens (Human)
Description:
P07900
Residue:
732
Sequence:
MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
  
Inhibitor
Name:
BDBM32185
Synonyms:
6-[5-(3-methoxy-4-oxidanyl-phenyl)pyrazolidin-3-ylidene]cyclohexa-2,4-dien-1-one | 6-[5-(4-hydroxy-3-methoxy-phenyl)pyrazolidin-3-ylidene]cyclohexa-2,4-dien-1-one | 6-[5-(4-hydroxy-3-methoxyphenyl)-3-pyrazolidinylidene]-1-cyclohexa-2,4-dienone | 6-[5-(4-hydroxy-3-methoxyphenyl)pyrazolidin-3-ylidene]cyclohexa-2,4-dien-1-one | CHEMBL210638 | TG2-101-2 | cid_6790395
Type:
Small organic molecule
Emp. Form.:
C16H16N2O3
Mol. Mass.:
284.3098
SMILES:
COc1cc(ccc1O)C1CC(N=N1)c1ccccc1O |c:13|
Structure:
Search PDB for entries with ligand similarity: