Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM41850
Substrate
n/a
Meas. Tech.
Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)
Ki
5000±n/a nM
Citation
 PubChem, PC Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent) PubChem Bioassay (2008)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
AMPC_ECOLI | Beta-lactamase | Beta-lactamase (AmpC) | Beta-lactamase AmpC | Cephalosporinase | Escherichia coli K-12 | ampA | ampC
Type:
Protien
Mol. Mass.:
41561.62
Organism:
Escherichia coli
Description:
P00811
Residue:
377
Sequence:
MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ
  
Inhibitor
Name:
BDBM41850
Synonyms:
2-[(1R)-1-carboxy-2-(1-naphthalenyl)ethyl]-1,3-dioxo-5-isoindolecarboxylic acid | 2-[(1R)-1-carboxy-2-(1-naphthyl)ethyl]-1,3-diketo-isoindoline-5-carboxylic acid | 2-[(1R)-1-carboxy-2-naphthalen-1-ylethyl]-1,3-dioxoisoindole-5-carboxylic acid | 2-[(2R)-3-naphthalen-1-yl-1-oxidanyl-1-oxidanylidene-propan-2-yl]-1,3-bis(oxidanylidene)isoindole-5-carboxylic acid | NCGC00161790-01 | cid_16752640
Type:
Small organic molecule
Emp. Form.:
C22H15NO6
Mol. Mass.:
389.3576
SMILES:
OC(=O)[C@@H](Cc1cccc2ccccc12)N1C(=O)c2ccc(cc2C1=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: