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Target
Cell division control protein 42 homolog
Ligand
BDBM43205
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant
EC50
1627±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant PubChem Bioassay (2010)[AID] 
Target
Name:
Cell division control protein 42 homolog
Synonyms:
CDC42 | CDC42_HUMAN | Cell division control protein 42 homolog | G25K GTP-binding protein | cell division cycle 42 (GTP binding protein, 25kDa)
Type:
PROTEIN
Mol. Mass.:
21258.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_652970
Residue:
191
Sequence:
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
  
Inhibitor
Name:
BDBM43205
Synonyms:
3-({[1-(1-Cyclopentyl-1H-tetrazol-5-yl)-2-methyl-propyl]-thiophen-2-ylmethyl-amino}-methyl)-8-methyl-1H-quinolin-2-one | 3-[[[1-(1-cyclopentyl-1,2,3,4-tetrazol-5-yl)-2-methyl-propyl]-(thiophen-2-ylmethyl)amino]methyl]-8-methyl-1H-quinolin-2-one | 3-[[[1-(1-cyclopentyl-5-tetrazolyl)-2-methylpropyl]-(thiophen-2-ylmethyl)amino]methyl]-8-methyl-1H-quinolin-2-one | 3-[[[1-(1-cyclopentyltetrazol-5-yl)-2-methyl-propyl]-(2-thenyl)amino]methyl]-8-methyl-carbostyril | 3-[[[1-(1-cyclopentyltetrazol-5-yl)-2-methylpropyl]-(thiophen-2-ylmethyl)amino]methyl]-8-methyl-1H-quinolin-2-one | MLS000031127 | SMR000004539 | cid_648964
Type:
Small organic molecule
Emp. Form.:
C26H32N6OS
Mol. Mass.:
476.637
SMILES:
CC(C)C(N(Cc1cccs1)Cc1cc2cccc(C)c2[nH]c1=O)c1nnnn1C1CCCC1
Structure:
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