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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43387
Substrate
n/a
Meas. Tech.
E3 Ligase_Mutant_Dose Response
EC50
4790±n/a nM
Citation
 PubChem, PC E3 Ligase_Mutant_Dose Response PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43387
Synonyms:
(E)-5-methyl-1-(2-sulfanylidene-1,3-benzoxazol-3-yl)-1-hexen-3-one | (E)-5-methyl-1-(2-sulfanylidene-1,3-benzoxazol-3-yl)hex-1-en-3-one | (E)-5-methyl-1-(2-thioxo-1,3-benzoxazol-3-yl)hex-1-en-3-one | 5-Methyl-1-(2-thioxo-benzooxazol-3-yl)-hex-1-en-3-one | MLS000557159 | SMR000173965 | cid_834844
Type:
Small organic molecule
Emp. Form.:
C14H15NO2S
Mol. Mass.:
261.339
SMILES:
CC(C)CC(=O)C=Cn1c2ccccc2oc1=S |w:6.5|
Structure:
Search PDB for entries with ligand similarity: