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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43489
Substrate
n/a
Meas. Tech.
E3 Ligase_Mutant_Dose Response
EC50
790±n/a nM
Citation
 PubChem, PC E3 Ligase_Mutant_Dose Response PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43489
Synonyms:
(E)-3-(4,6-dimethylpyrimidin-2-yl)sulfanyl-1-phenyl-prop-2-en-1-one | (E)-3-(4,6-dimethylpyrimidin-2-yl)sulfanyl-1-phenylprop-2-en-1-one | (E)-3-[(4,6-dimethyl-2-pyrimidinyl)thio]-1-phenyl-2-propen-1-one | (E)-3-[(4,6-dimethylpyrimidin-2-yl)thio]-1-phenyl-prop-2-en-1-one | 3-[(4,6-dimethylpyrimidin-2-yl)thio]-1-phenylprop-2-en-1-one | MLS000851115 | SMR000457358 | cid_5713202
Type:
Small organic molecule
Emp. Form.:
C15H14N2OS
Mol. Mass.:
270.349
SMILES:
Cc1cc(C)nc(S\C=C\C(=O)c2ccccc2)n1
Structure:
Search PDB for entries with ligand similarity: