Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM43787
Substrate
n/a
Meas. Tech.
SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay
EC50
11200±n/a nM
Citation
 PubChem, PC SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay PubChem Bioassay (2009)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM43787
Synonyms:
1-[(4-ethyl-5-methyl-thiophen-3-yl)carbonylamino]-3-(oxolan-2-ylmethyl)thiourea | 1-[(4-ethyl-5-methyl-thiophene-3-carbonyl)amino]-3-(tetrahydrofurfuryl)thiourea | 1-[(4-ethyl-5-methylthiophene-3-carbonyl)amino]-3-(oxolan-2-ylmethyl)thiourea | 1-[[(4-ethyl-5-methyl-3-thiophenyl)-oxomethyl]amino]-3-(2-oxolanylmethyl)thiourea | MLS-0231795.0001 | cid_4607710
Type:
Small organic molecule
Emp. Form.:
C14H21N3O2S2
Mol. Mass.:
327.465
SMILES:
CCc1c(C)scc1C(=O)NNC(=S)NCC1CCCO1
Structure:
Search PDB for entries with ligand similarity: