Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM43810
Substrate
n/a
Meas. Tech.
SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay
EC50
8410±n/a nM
Citation
 PubChem, PC SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay PubChem Bioassay (2009)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM43810
Synonyms:
1-[(4-chloranyl-2,5-dimethyl-pyrazol-3-yl)carbonylamino]-3-(4-methylphenyl)thiourea | 1-[(4-chloro-2,5-dimethyl-pyrazole-3-carbonyl)amino]-3-(p-tolyl)thiourea | 1-[(4-chloro-2,5-dimethylpyrazole-3-carbonyl)amino]-3-(4-methylphenyl)thiourea | 1-[[(4-chloro-2,5-dimethyl-3-pyrazolyl)-oxomethyl]amino]-3-(4-methylphenyl)thiourea | MLS-0228958.0001 | cid_842682
Type:
Small organic molecule
Emp. Form.:
C14H16ClN5OS
Mol. Mass.:
337.828
SMILES:
Cc1nn(C)c(C(=O)NNC(=S)Nc2ccc(C)cc2)c1Cl
Structure:
Search PDB for entries with ligand similarity: