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Target
Mannose-6-phosphate isomerase
Ligand
BDBM33049
Substrate
n/a
Meas. Tech.
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50
19574±n/a nM
Citation
 PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay (2009)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM33049
Synonyms:
(4-chlorodithiazol-5-ylidene)-(3,5-dimethoxyphenyl)amine | 4-chloranyl-N-(3,5-dimethoxyphenyl)-1,2,3-dithiazol-5-imine | 4-chloro-N-(3,5-dimethoxyphenyl)-5-dithiazolimine | 4-chloro-N-(3,5-dimethoxyphenyl)dithiazol-5-imine | MLS000044018 | N-[(5Z)-4-chloro-5H-1,2,3-dithiazol-5-ylidene]-N-(3,5-dimethoxyphenyl)amine | SMR000021429 | cid_715724
Type:
Small organic molecule
Emp. Form.:
C10H9ClN2O2S2
Mol. Mass.:
288.774
SMILES:
COc1cc(OC)cc(c1)\N=c1\ssnc1Cl
Structure:
Search PDB for entries with ligand similarity: